Past Projects

PAST 3-D CELL/TISSUE ORGANOID-LIKE  PROJECTS
Cell Systems 3-D has designed and bioengineered numerous prototype 3-D models for investigations in the pathophysiology of microbial, viral and fungi pathogens.
These 3-D models have been used in NIH or privately  sponsored research.

VIROLOGY

• Proof of concept; human cerebellum 3-D model for invasiveness and pathology of West Nile Virus, (NY-99 strain) and Dengue-2.
• Pathophysiology of SARS-coronavirus  (SARS-CoV, Urbani strain) in a human upper airways 3-D model.
• Pathophysiology of Respiratory Syncytial Virus (wt-A2) and proof of concept for Parainfluenza 1 and 3 in a 3-D human airways model.
• Pathophysiology of Epstein-Barr Virus (EBV) in a human endovascular – pharyngeal epithelia 3-D model.
• Proof of concept 3-D mosquito Ae. albopictus 3-D model for arbovirus transmission.

MICROBIAL

• Proof of concept;  3-D human colon model for Mycobacterium spp. invasiveness and pathophysiology.

PARASITOLOGY

• Proof of concept; normal human dermis providing a microenvironment for filarid nematode development from infective larvae to adult.
• Proof of concept; Human small intestine model for life cycle stage development of Cryptosporidium parvum.

VETERINARY

• Proof of concept;  avian chick small intestinal model for selected bacterial pathogens.
• Proof of concept; neonatal bovine small intestine-colon for selected bacterial pathogens.
• Proof of concept; tick mid-gut cell model for proteomic comparisons between in-stage and adult tissue.